A new study on the testing strategy coronavirus and monitoring of Duke University published Tuesday in the Center for Disease Control and morbidity Prevention and Mortality Weekly Report highlights the importance of widespread testing of asymptomatic individuals to prevent transmission and provides support for the feasibility of a combined approach, in which Multiple samples are combined into a single test run.

Duke study adds to the evidence in support of the mass frequent testing of all students on campus. A study published last summer by researchers from Harvard and Yale in JAMA open network also argued the need for frequent monitoring of asymptomatic tests students in order to prevent outbreaks of the campus. But that was a modeling study of a hypothetical cohort of students, while Duke campus is based on real-world data testing this fall.

During the first 10 weeks of the fall semester, Duke 68.913 tests conducted 10,265 students. Just over half (51 percent) of the 84 total students who tested positive were asymptomatic - "that a substantial proportion of infections was lost with the only symptomatic evidence", a finding that suggests that, as the article says,

"some of these people had some numbers very high viral load: which means that the amount of virus they had when we tried," said Thomas Denny, the lead author of the article, professor of medicine at Duke University School of Medicine and chief of operations at the Duke Human Vaccine Institute. "They are asymptomatic, they do not know they are infected and have a very high viral load them. If those people are walking in dorms or classrooms, where the risk of planting a large number of infections run. "

A recent analysis by the initiative of the University of crisis in Davidson College in Carolina of the North found that only a quarter of the schools are carrying out mass screening or regular monitoring of student test this fall, and only 6 percent are testing routinely all students. Most schools did not have a plan of clear evidence or are only testing students who are symptomatic or have had known exposure to COVID-19.

Denny and his co-authors argue that their findings "underscore the importance of evidence combination and contact tracing beyond symptomatic testing strategies, in partnership with other preventive measures." Above all, the article argues that the testing program at Duke frequent monitoring combined with risk reduction measures "likely contributed to a prolonged period of low transmission on campus period."

included requires testing strategy Duke entrance tests students on their return to school this fall, frequent screening combined asymptomatic students and tests for symptomatic students and exposed, combined with the contact tracing and quarantine measures. Since 20 September, the university has proven residential students twice a week, outside the campus undergraduate students once or twice a week and graduate students about once a week.

for screening surveillance, Duke pooled samples from five different students in one combined sample for testing. Positive pools is in position "deconvolution" or more tests of each of the five individual samples.

The article argues that grouping samples "can allow large-scale testing and reduce to the minimum the necessary resources."

"For the combined test, the time between sampling, the return of a positive set after deconvolution, and returning clinical outcomes was 18-30 hours," the authors write. "In addition, tests grouped allowed for about 80 percent savings in the use of laboratory reagents and resources compared to test each individual sample."

Of the 84 students who tested positive, nine cases were detected using tests you input, 29 cases were identified by testing asymptomatic pooled and 23 contact Tracin


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